Apart from the fear of showing up as someone who 'hops' too frequently, there is the added requirement of settling into a new place and adjusting to it effectively. Each time you undertake a job search, you are bracing up for a new workplace, new colleagues to interact with, and probably, a whole new lifestyle. This is particularly true when you take up a new job in a different place altogether. Apart from managing your professional life, you need to also take into account life in a new place. In case you have children who will be moving with you, this transition can get a little more difficult. You will probably be looking for a house as well as a suitable school for them; all the while juggling your own professional challenges.
However, a job change can also mean a change in careers totally. Often, people are extremely unhappy in their workplaces and may find that changing jobs does not really help. A total career shift may help in this case; only, it comes with its own share of stress. Very often people are caught in highly successful careers, but are unhappy with the work they are doing. If the cause for dissatisfaction is dependent on the compensation, or the work environment, or even on co-workers, a change of job might help the situation. But if the dissatisfaction is due to a deeper cause, a change in career might be necessary to sort out things and prevent a total burnout.
If the entire family is to be affected by the professional change, understanding the underlying reason for the job or career change is very important for each member. This is the only way emotional stress over the shift can be distributed and reduced.